Lys Mousset and David McGoldrick lead the line again, while Billy Sharp and Oli McBurnie are on the bench.
United, making their first ever visit to the Tottenham Hotspur Stadium, have also named the same substitutes as last weekend’s 3-0 win over Burnley.
Spurs: Gazzaniga, Aurier, Dier, Sanchez, Davies, Sissoko, Ndombele, Lo Celso, Dele, Son, Kane. Subs: Vorm, Alderweireld, Foyth, Winks, Sessegnon, Eriksen, Lucas.
Blades: Henderson, Baldock, Stevens, Fleck, O'Connell, Basham, Lundstram, Egan, Norwood, McGoldrick, Mousset. Subs: L. Freeman, McBurnie, Sharp, Robinson, Jagielka, Moore, Bešić.