But how did the Blades players fare? Our man offers his player ratings.
1. Dean Henderson 6
Got a talking-to from his defenders for not coming for one ball in the first half and his afternoon will ultimately be remembered for his error as Wijnaldum's shot squirmed through his hands. Made a top save to deny Salah afterwards when one-on-one | JPIMedia Photo: Simon Bellis
2. Chris Basham 8
A few hairy moments, including one losing the ball to Origi in his own box, but was part of a back three that kept the Reds' fabled forwards quiet for most of the game. Did superbly well to dispossess Robertson early in the game on the overlap | Getty Images Photo: Nathan Stirk
3. Jack O'Connell 8
Did not deserve to end on the losing side against his boyhood club. Threw his body in the way of everything and was left disconsolate on the turf when the winning goal went in | PA (Press Association) Photo: Shaun Botterill
4. Enda Stevens 8
Had a difficult job, keeping Alexander-Arnold quiet, and did it superbly. Was forced to defend late on as United threw bodies forward, and snuffed out one chance against Salah brilliantly | JPIMedia Resell Photo: Simon Bellis