Here we take a look at some of the best and worst performances the Blades have produced in recent years in the third round of the world-famous competition.
5. Arsenal, 1996
Carl Veart stoops low to head home the only goal of the game for the Blades against Arsene Wenger's Arsenal in a third round replay at Bramall Lane in 1996. Photo: unknown
6. Ipswich Town, 2018
Nathan Thomas celebrates scoring the winner for the Blades against Ipswich Town at Portman Road in 2018. Photo: PA. Photo: PA
7. Aston Villa, 2014
Sheffield United players celebrate Ryan Flynn's goal in the 2-1 win at Premier League Aston Villa in 2014. Photo: PA. Photo: David Davies
8. Colchester United, 2006
A frustrated Neil Warnock shouts from the touchline during his side's 2-1 home defeat to League One outfit Colchester United in 2006. Photo: Dean Atkins