The striker had only just returned from a hamstring injury in United’s last game against Cardiff City, before sustaining the injury in training ahead of the crunch Championship clash.
United are sixth in the table with two games left but have teams breathing down their necks as they look to nick a play-off place from Paul Heckingbottom’s men.
Blades: Foderingham, Stevens, Fleck, Basham, Berge, Egan, Norwood, Robinson, Osborn, Gibbs-White, Ndiaye.
Subs: A. Davies, B. Davies, Hourihane, Uremovic, Osula, Norrington-Davies, Jebbison.
For QPR, former Wednesday goalkeeper Kieren Westwood misses out, meaning youngster Murphy Mahoney makes just his second first-team appearance.
QPR: Mahoney, Adomah, Sanderson, Dunne, McCallum, Field, Dozzell, Amos, Johansen, Chair, Austin.
Subs: Halwax, Kakay, Ball, Hendrick, Thomas, Dykes, Gray.