McGoldrick replaces Billy Sharp in the only change to the Blades’ line-up.
The Blades have a full complement of substitutes on the bench, but there is no sign of John Fleck in the squad as the Scottish midfielder continues his recovery from injury.
Frank Lampard makes two changes for Chelsea.
Jorginho replaces the injured Billy Gilmour in midfield, while Tammy Abraham starts up front.
Blades: Henderson, Baldock, Stevens, O'Connell, Basham, McBurnie, Egan, Norwood, McGoldrick, Osborn, Berge.
Subs: Lundstram, Sharp, Jagielka, K. Freeman, Robinson, Mousset, Moore, Rodwell, Živković.
Chelsea: Kepa; James, Zouma, Christensen, Azpilicueta (c); Barkley, Jorginho, Mount; Willian, Abraham, Pulisic.
Subs: Caballero, Rudiger, Alonso, Bate, Kovacic, Loftus-Cheek, Hudson-Odoi, Batshuayi, Giroud.