David McGoldrick comes in for Callum Robinson up front, while John Fleck returns from injury to replace Luke Freeman in midfield.
Both Robinson and Freeman are amongst the substitutes.
Che Adams, the former Blade, starts for the Saints.
Blades: Henderson, Baldock, Stevens, Fleck, O'Connell, Basham, Lundstram, McBurnie, Egan, Norwood (c), McGoldrick. Subs: Freeman, Sharp, Robinson, Mousset, Osborn, Moore, Bešić.
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Saints: Gunn, Cédric, Vestergaard, Bednarek, Yoshida, Højbjerg (c), Romeu, Ward-Prowse, Boufal, Djenepo, Adams. Subs: McCarthy, Stephens, Bertrand, Valery, Armstrong, Long, Ings.