David McGoldrick is back from his recent injury to start upfront, alongside Lys Mousset.
John Fleck is also passed fit to play.
Oli McBurnie drops to the bench after it emerged today that he has been charged with drink-driving.
Callum Robinson is also amongst the substitutes.
Arsenal, meanwhile, make one change from their last Premier League game. Joe Willock returns, at the expense of Dani Ceballos.
Blades: Henderson, Baldock, Stevens, Fleck, O'Connell, Basham, Lundstram, Egan, Norwood, McGoldrick, Mousset. Subs: L. Freeman, McBurnie, Sharp, Robinson, Jagielka, Moore, Bešić.