Three of those are enforced, with John Egan serving a one-match suspension for his handball against Millwall last week while Billy Sharp and Chris Basham nurse hamstring injuries.
In come Gary Madine, Richard Stearman, Martin Cranie and George Baldock, who replaces Kieron Freeman in the other non-enforced change.
Blades: Henderson, Baldock, Cranie, Stearman, O’Connell, Stevens, Fleck, Norwood, Duffy, McGoldrick, Madine. Subs: Lundstram, Dowell, Hogan, Coutts, Freeman, Moore, Washington.
Forest: Pantilimon, Colback, Murphy, Wague, Cash, Yates, Lolley, Yacob, Byram, Pele, Benalouane. Subs: Grabban, Watson, Osborn, Steele, Milosevic, Ansarifard, Appiah.