
The Argentinian had spent five-and-a-half years in North London and helped take Spurs to the Champions League final last season where they lost to Liverpool.
However, a poor start to this campaign has seen the team tipped as title contenders sit 14th in the Premier League.
Pochettino’s last game in charge before the international break was a home draw with Sheffield United – a match in which the visitors deserved to take all three points.
Chairman Daniel Levy, who appointed Pochettino in June 2014, said: "We were extremely reluctant to make this change and it is not a decision the board have taken lightly, nor in haste.
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"Regrettably domestic results at the end of last season and the beginning of this season have been extremely disappointing.
"It falls on the board to make the difficult decisions - this one made more so given the many memorable moments we have had with Mauricio and his coaching staff - but we do so in the club's best interests."
Tottenham take on West Ham this weekend.