Slavisa Jokavonic’s men come up against Birmingham City on Saturday evening, and will be aiming to get their promotion hopes off to a positive start with a win.
Last season, the Blades were beaten 2-0 by Wolves in the opening match of their Premier League campaign, but how are they likely to get on this time around?
The boffins at Bookmakers.tv have been flicking back through the history books to see how every Championship club have fared on their 10 most recent opening day outings, and we’ve compiled a league table showcasing the results.
Will it be a positive return to action in the second tier for Jokanovic’s side, or will it be disappointment at the first hurdle?
Click and scroll through the pages below to read our countdown of all the standings...