Striker Daniel Jebbison has been named in the England U18 squad to face Wales on March 29 - and he could face Blades teammate Ryan Viggars, who is in the Wales squad.
And Antwoine Hackford, who became United's youngest-ever Premier League player in January away at Crystal Palace, has been called up by England U17s for a four-day training camp at the end of this month.
Hassan Ayari has also returned to Shirecliffe after helping Tunisia's U20s squad reach the semi-finals of the African Cup of Nations.
"This international recognition is testament to the fantastic work going on right through the Academy, from a passionate and talented group of staff.
"It is an exciting time for the club as there is some brilliant talent progressing through various age groups."