Providing it doesn’t fall victim to the elements, the game will pit the Championship’s second and fifth-placed teams against each other in South Yorkshire as the Blades look to consolidate their grip on second place.
Boss Paul Heckingbottom says Iliman Ndiaye and James McAtee are “fine” after limping off against the Royals, while a key man is also available again for selection after suspension.
So we tasked our man to step into Heckingbottom’s smart shoes and pick the side he would send out to face Rob Edwards’ side. Here's what he came up with – what would you do differently?
5. Jack Robinson
One of United’s most consistent performers of late, Robinson’s ever-combative style could be well-suited to the Luton test while his long throw is another weapon in United’s armoury Photo: Michael Regan
6. Max Lowe
I’ve been advocating Ben Osborn at wing-back for some time but his injury, plus Lowe’s improved showing at Reading, means the former Derby man gets the nod Photo: Paul Terry
7. Ollie Norwood
United need to find a way to get Norwood on the ball and dictating play because when he plays well, so do United invariably. The return of Doyle in my side would perhaps help with that Photo: Simon Bellis
8. Tommy Doyle
Rarely seen after his man of the match display against Tottenham in the FA Cup, Doyle may return to the side after playing only 14 minutes in the last couple of league games Photo: Paul Thomas