The Blades are expected to part company with the 53-year-old, with an announcement potentially on the cards for later today.
Wilder’s side have been rooted to the foot of the table for much of the campaign, and are currently 12 points adrift of safety with just 10 games left to play.
The manager has been in charge of United for five years, taking them from League One up to the top flight, but his relationship with the board of directors is known to have been strained for some time, with cracks beginning to publicly emerge following January’s transfer window.
A month prior, Blades owner HRH Prince Abdullah bin Musa’ad bin Abdulaziz Al Saud insisted that he wanted Wilder to remain in charge whether United were relegated or not.
However, tensions between coaching staff and members of United’s hierarchy grew when a block was effectively put on transfers during the winter window.
Reacting to reports of Wilder's imminent departure on social media, Sky Sports pundit Kamara wrote on his personal Twitter account: “Chris Wilder sacked.
"The game I love is crazy at times.
"Not heard any of the fans shouting for his head but as a manager you do expect the unexpected.
"Well done Chris - despite current position in the table, what a great five years you have had”.
Paul Heckingbottom is expected to step in as caretaker manager at Bramall Lane for the time being.