From the chastening 4-1 defeat at Coventry City on Saturday, Paul Heckingbottom has recalled Iliman Ndiaye in place of Conor Hourihane.
An already-young bench has been shuffled to include striker Will Osula and defender Nickseon Gomis, as well as 17-year-old Oli Arblaster.
Sheffield Wednesday's crucial Lee Gregory update as new signing is ruled out 'for some time'
Sheffield Wednesday injury update on Michael Smith, concerns cooled over defensive pair
Who is Luke Cook? Sheffield Wednesday new signing who made debut v Sunderland
“Duracell bunny” “Could’ve done a crossword” – Player ratings as Sheffield Wednesday cruise to win over Sunderland
"They sat behind the ball" - Sunderland boss talks Sheffield Wednesday tactics after Owls win in Carabao Cup
Blades: Foderingham, Osborn, Gordon, Egan, Robinson, Norrington-Davies, Norwood, Berge, Ndiaye, Gibbs-White, Sharp.
Subs: A. Davies, Hourihane, Lopata, Osula, Jebbison, Arblaster, Gomis.
Blackpool: Grimshaw, Sterling, Ekpiteta, Thorniley, Connolly, Husband, Stewart, Dougall, Bowler, Hamilton, Madine.
Subs: Moore, James, Robson, Kirk, Dale, Yates, Lavery.