The 33-year-old frontman makes only his second Premier League start of the season, with Lys Mousset dropping to the bench.
Wilder has also made a change in midfield with Mo Bešić replacing John Lundstram.
Here’s how United fans have reacted on Twitter to the manager’s team selection tonight.
@keithwall1955 #twitterblades Nice to see Besic get a start as I think Lunny needs a rest. Is McGoldrick still injured or are the transfer rumours correct ?? Also nice to see Billy get a start but rightly or wrongly I feel it could be his last game for us even though he says he wants to stay.
@djSJBirds Absolutely delighted to see @billysharp10 getting his first PL start for the mighty Blades
@JordLowe1993 Sharp and McBurnie, same player. No pace options there when we are gunna have 28% possession
@molliedalton10 Sharp hat-trick incoming
@benscribbles Billy starts. Can’t wait for this.
@Utdsback3 I know he wants game time but he’s not good enough to start.
@JohnnyFaz90 Billy starting against the champions of England for HIS club in the Premier League ... love to see it. #sufc #twitterblades
@HispanicHammer The living Legend gets the start AND the armband today
@ViewFromJohnSt Just our luck! Laporte, widely regarded as man Man City have been lacking to launch title defence, returns from injury at Bramall Lane. Job just got a bit more difficult. #sufc #twitterblades