But the ground has also played host to events such as rock concerts, American evangelist Billy Graham as well as world title boxing bouts, rugby league matches and Ashes cricket – with the sound of willow on leather first echoing around the Lane in 1855.
It has staged the first floodlit football match, England football internationals and an FA Cup final replay, while it was also badly damaged in the Sheffield Blitz during the Second World War.
Here we take a look at the changing face of Bramall Lane down the years, from a cricket ground steeped in history to a modern-day stadium fit for Premier League football.
. Yorkshire v Lancashire County Cricket Match at Bramall Lane in August 1967. Geoff Boycott had an outstanding match
Twenty-two photos of Sheffield United's Bramall Lane. Photo: Sheffield Archives
. Bramall Lane through the years
Bomb damage to Bramall Lane during the Sheffield Blitz on December 12 1940. Photo: JPI Media
. Bramall Lane through the years
Legendary England cricketer Jack Hobbs and Phil Mead go out to bat during a Test Trial match in June 1911. Photo: Topical Press Agency, Getty Images
. Bramall Lane through the years
The Shoreham Street side of the ground was badly damaged by storms in February 1962. Photo: Colin Drury
. Bramall Lane through the years
Snow is cleared from the pitch in February 1963. Photo: Sheffield Newspapers Ltd
. Bramall Lane through the years
Yorkshire host Roses rivals Lancashire at the Lane in August 1967. Photo: Sheffield Archives
. Bramall Lane through the years
Players from Yorkshire and old enemy Lancashire walk off in the final County Championship match to be played at the famous, old ground in August 1973. Photo: Chris Lawton
. Bramall Lane through the years
Geoff Boycott leads the Yorkshire players out onto the Bramall Lane pitch in August 1973. Photo: ©Sheffield Newspapers Ltd
. Bramall Lane through the years
Geoff Boycott and Richard Lumb take to the field for their final innings at Bramall Lane in August 1973. Photo: ©Sheffield Newspapers Ltd
1. Bramall Lane through the years
Bomb damage to Bramall Lane during the Sheffield Blitz on December 12 1940. Photo: JPI Media
2. Bramall Lane through the years
Legendary England cricketer Jack Hobbs and Phil Mead go out to bat during a Test Trial match in June 1911. Photo: Topical Press Agency, Getty Images
3. Bramall Lane through the years
The Shoreham Street side of the ground was badly damaged by storms in February 1962. Photo: Colin Drury
4. Bramall Lane through the years
Snow is cleared from the pitch in February 1963. Photo: Sheffield Newspapers Ltd