Manchester United and non-league Crawley will meet at Old Trafford in the fifth round of the FA Cup.
The draw at Wembley paired the Premier League leaders with the Blue Square Premier side, who have knocked out league sides Swindon, Derby and Torquay on their way to the last 16.
Leyton Orient were also given a glamorous tie - the League One side will face Arsenal at Brisbane Road.
Holders Chelsea will face Reading for a place in the quarter-finals - if Carlo Ancelotti’s team win their replay against Everton on February 19.
League One Notts County and Manchester City must replay after today’s 1-1 draw at Meadow Lane - with Aston Villa awaiting the winners.
London will meet the north-west in two ties, with either Fulham or Tottenham taking on Bolton or Wigan and West Ham and Burnley squaring up at Upton Park.
Stoke will have home advantage against League One Brighton, while Birmingham and Sheffield Wednesday will meet in the other tie.
Crawley boss Steve Evans was delighted with the draw.
He said: “It (getting paired with United) was just a surreal moment.
“We got the tie that everyone in the country wants. I suppose if you are Arsene Wenger or Alec McLeish you don’t want that draw - but we did.
“We will approach the tie in a really positive nature.
“The only non-league club capable of beating Manchester United is Crawley Town as we stand today ... miracles do happen.”
He added: “This is going to be the biggest day in our lives but we will give them the respect that Real Madrid gave them ... the utmost respect.”
Leyton Orient chairman Barry Hearn is looking forward to the tie against Arsenal.
He said: “We’re in danger of breaking even - I don’t what’s happening these days with football!
“But the money is secondary. I’ve been chairman for nearly 16 years and we’ve never had anything like this. It’s going to be a fabulous day out. I love the FA Cup.”
Hearn insists the visit of Arsenal is more significant to him than a clash against neighbours West Ham would be.
He added: “We are two teams from the East End - we know each other too well. It’s great to bring Arsenal down from north London."
West Ham v Burnley
Notts County/Manchester City v Aston Villa
Stoke v Brighton
Birmingham v Sheff Wed
Leyton Orient v Arsenal
Everton/Chelsea v Reading
Manchester United v Crawley
Fulham v Bolton/Wigan
Matches to be played on the weekend of February 19-20.