Chesterfield’s Proact Stadium was graced by a screamer of a free-kick when the Spireites met the Shrimpers in August 2013.
Gary Roberts curled a beautiful effort into the net to give Town the lead, before Southend hit back through Freddy Eastwood.
But in injury time substitute Armand Gnanduillet rose above everyone to head the ball home and ensure the points stayed at the Proact.
Danny Wilson takes his men to Roots Hall on Saturday hoping for a repeat of the corresponding fixture last season, when Chesterfield won 1-0.
At home against Southend last season Town won 3-0, with two goals from Sylvan Ebanks-Blake and a Novak strike.
See the highlights of that game HERE