Sharrow Vale Road is also home to one of the city’s best-loved pubs, a bustling street market and a historic and picturesque old snuff mill.
It stretches from Hunter’s Bar roundabout, at the bottom of Endcliffe Park, to Cemetery Road, at the top of the historic Sheffield General Cemetery.
This retro photo gallery shows how it has changed over more than 100 years, from the late 1800s to the end of the 20th century.
It charts the businesses which have come and gone, and those which have stood the test of time, along with some of the characters who have worked in them down the decades.