But while these institutions may have physically disappeared, many of us still remember them. From the strange nights hosted at Josephine's to the mecca of all toy shops, Redgates, we take a look back at the treasures the city has lost over the years.
Redgates Toy Shop was regarded as one of the best outside of London and was a big favourite with the city's children. It had several locations, including one temporary move to Ecclesall Road after being bombed in the Blitz.
Though Sheffield has one Odeon remaining at Arundel Gate, two other historic Odeons in Flat Street and Burgess Street have been lost to the ages.
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Gatecrasher One was a legendary Sheffield nightclub that caught fire in 2007, leading ultimately to the demolition of the building.
Roxy disco was a legendary spot for pop-loving revellers in the 80s and 90s, with stars like Kylie Minogue and Jason Donovan among the club's star-studded guests. It closed in the late 90s and the site is now home to the O2 Academy.
Music factory was a must for all Sheffield house lovers, and got extra points for its quirky location - inside an old library. The club was later re-named as "Bed" before the building was demolished to make way for retail units.
One of Sheffield's most beloved independent book, art and music shops, Rare and Racy was forced to close in 2017 after 48 years of trading due to the pressures of modern high-street trading.
Josephine's had a strange - but legendary - reputation in Sheffield as a club cum restaurant cum wine bar. It had a strict door policy, so punters were never quite sure whether they'd get in or not.
The Boardwalk was a music venue that hosted scores of huge names over the years, including AC/DC, the Clash, the Sex Pistols and The Arctic Monkeys. The latter's first music demo was even titled "Beneath the Boardwalk."
The Harley is another treasured Sheffield music venue to feel the squeeze in recent years. It's hosted the likes of Zed Bias, Plastician, and Midland but has been forced by "mounting financial pressures" to shut down.
Harrison was a designer shop that stocked famous brands like Paul Smith and Hugo Boss, first opened in 1987. However after a series of raids on the store, it is being closed by the owner who can no longer cope.