Wet snow has already been reported in parts of Sheffield this morning and parts of the Peak District and Derbyshire have seen roads blocked.
Rain or snow showers have been forecast for Wednesday morning between 4am-6am in the Sheffield area.
Overnight temperatures will fall to 3C but it will feel more like -2C as the wind bites.
Over high ground, showers are likely to be sleety with perhaps some wet snow as well.
Snow and ice are predicted to disrupt commuters today (Tuesday January 28) across large parts of Britain, where four yellow warnings are in place.
It may have fallen short of predictions it would be winter's coldest night but the cold air overnight still managed to bring snow, sleet and rain across Scotland and England's north-west.
The air that has pushed south from Greenland ensured a low of minus 4C (25F) was recorded on The Cairnwell mountain in the Eastern Highlands, the Met Office's Helen Roberts said.
The cold air combined with a band of precipitation to produce sleet and snow, as well as icy patches, which could prove problematic for those in cars and on trains, the forecaster added.
"It'll be an icy start for many, with a widespread frost and temperatures dipping just below freezing," she said.
Up to 15cm of snowfall has been predicted in some places.
About 750 road-gritting lorries - 500 in Scotland and 250 in England - are ready to be deployed, the Daily Mirror has reported.