The experienced wide man, recruited on a free transfer last summer, has not featured since September 9 due to injury.
Boyd sustained a shoulder problem and went under the knife. But surgery failed to fix the problem and Boyd was forced to have another operation in October.
Following a lengthy injury lay-off, Boyd has resumed full training and could be involved in Saturday’s tie at Brunton Park.
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Caretaker Wednesday boss Lee Bullen said: “George Boyd is back. He will be available for selection for Carlisle.”
Bullen confirmed Jack Hunt tweaked his knee again in Monday’s home humbling to Burton Albion.
“It ballooned a little bit and that’s why we had to take Jack off,” said Bullen.
Captain Glenn Loovens (illness) was brought off at half-time and replaced by Daniel Pudil as the Owls slumped to a third successive Hillsborough defeat.
Bullen said: “Glenn Loovens played with a major illness down at Brentford and we had to try and shoehorn him back in today. To be fair, he probably should not have started the Burton game and I asked him to do it. We brought Danny on at half-time.”