A police cordon is in place on a Sheffield city centre road, causing long delays.
The top of Nursery Street has been cordoned off by police near Bridgehouse Roundabout and the Riverside pub.
Cars were not able to turn left down Nursery Street.
UPDATE: The road has now reopened, police have confirmed.
A bus has been parked near the scene of the incident with its hazard lights on, but it is not yet confirmed whether it was involved in the incident.
A South Yorkshire Police spokesman said: "There was a collision and the road was closed while emergency services responded.
"Road now reopen."