Officers from Sheffield West neighbourhood police team said they received a call that three men had forced entry to an address on Howard Road, Walkley.
When they arrived, they found the property was home to a '˜comprehensive' cannabis factory with all floors being used to grow the drug.
Sgt Dave Cremin said: 'Officers were very quick on scene to detain three men,Â who were arrested on suspicion of burglary and cultivation of cannabis.
'The address housed a comprehensive cannabis factory set up with all floors being used. The investigation continues and the immigration team also have an interest in those arrested.'