Emergency services were called to Ship Hill, in Rotherham, following reports of a car crash shortly before 12pm today.
Fire crews from Rotherham and Elm Lane stations attended the scene.
Operator First South Yorkshire said: “Ship hill is closed due to a RTC buses are operating via Mansfield road inbound to city only.”
South Yorkshire Fire & Rescue said that only one car was involved in the collision.
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The occupants of the car have been taken to hospital following the crash.
Police said the road has now reopened to both vehicles and pedestrians.