Police said they were called to Melton Road in Doncaster at around 4pm today to ‘reports of a collision involving two cars and a pedestrian’.
They said at 7pm that the road remained closed and officers were still at the scene.
Doncaster Council said at 6pm that Sprotbrough Road had been closed from the Ivanhoe pub at the top of Melton Road, up to KFC, and was likely to remain shut for the ‘majority of the evening’.
It later tweeted to say the closure was now in place from Newton Lane and Allendale Gardens to Spring Lane, near the Ivanhoe.
Police have yet to release further information about the collision, including details of any injuries to those involved.
The road remained closed at 9pm today and Stagecoach Yorkshire said the number 49 from Doncaster to Sprotbrough had been suspended due to the closure.
Anyone with information is asked to call South Yorkshire Police on 101.