The fault has been resolved and trains between Sheffield and Manchester Piccadilly are returning to normal but may still be delayed by up to 60 minutes, cancelled or diverted.
Disruption is expected until around 1.30pm.
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East Midlands Trains between Norwich, Nottingham and Liverpool Lime Street are affected along with Northern services between Sheffield and Manchester Piccadilly and TransPennine Express express trains between Cleethorpes and Manchester Airport.