He takes a place on the bench, as expected, after Jos Luhukay confirmed his availability yesterday.
Forestieri has been recovering from surgery on a cruciate ligament injury and hasn't played since the Carabao Cup defeat to Bolton in August.
The forward made his first return to action for the under 23s against Coventry on Monday, scoring a penalty.
Barry Bannan also makes a return to starting action - the Scot came off the bench against Leeds before the international break.
Lucas Joao has dropped to the bench - Atdhe Nuhiu plays up front, with Adam Reach expected to play in behind the front man. Morgan Fox returns to the left of the defence, with George Boyd left out.
Sheffield Wednesday: Wildsmith, Hunt, Lees, Venancio, Pudil, Fox, Hutchinson, Pelupessy, Bannan, Reach, Nuhiu. Subs: Dawson, Palmer, Jones, Butterfield. Joao, Rhodes, Forestieri.