The former Sunderland midfielder appeared as a substitute for Tony Mowbray's side during last weekend's draw with Nottingham Forest and, despite conceding a penalty, impressed the Lancastrian's manager.
"I thought Rodwell, in the short time he was on, showed that he's mobile, he's athletic, understands the game and it was unfortunate for him to be involved in the penalty incident," Mowbray said. "Jack Rodwell will be all right for us I'm sure, he just needs opportunities."
Rodwell moved to Rovers earlier this season after spending four years on Wearside. The switch to Ewood Park represents a chance to rebuild his career and reputation following a series of well-documented problems at the Stadium of Light. Despite earning a reported Â£43,000 a week, Rodwell made only six appearances as Sunderland were relegated from the Championship last term.
Mowbray, who led Rovers to promotion earlier this year, enters the meeting with United having lost only twice at home in the past 12 months. Derrick Williams' return from suspension, coupled with hopes Charlie Mulgrew could feature after overcoming an injury, will bolster his hopes of preserving that record against Chris Wilder's team.
"We're hopeful of Mulgrew being ready for Wednesday," Mowbray said. "Williams' suspension is over so we have some decisions to make for the next game."