As the main road running through Hillsborough, it has seen many changes over the years.
This retro photo gallery charts the evolution of Middlewood Road in Sheffield from the early 1900s to the 1990s.
It features lost shops, old pubs and some popular characters who have run them over the years.
The old trams and the new Supertram system which eventually replaced them are pictured, along with Wharncliffe War Hospital, which later became Middlewood Hospital, Hillsborough Park Cinema and the Hillsborough Inn.
The photos are shared courtesy of Picture Sheffield. Do they bring back any memories for you?
It features lost shops, old pubs and some popular characters who have run them over the years.