He took to the stage to collaborate with Beck as part of his European tour.
They played together and Mr Depp sang on Isolation, a cover of a John Lennon song the pair released together as a duo in 2020.
The Pirates of the Caribbean star is not the first A-list celebrity to be welcomed to the city.
From actors and TV personalities to famous musicians, here is a selection of some of the city’s most recent celebrity sightings.
1. Johnny Depp on stage with Jeff Beck
The Hollywood actor on stage with the guitar hero. Photo: submit
2. Jodie Whittaker
In February 2018, Doctor Who fans flocked to the Park Hill as Jodie Whittaker was seen filming for the new season. Photo: Anthony Devlin / Getty
3. Sylvester Stallone
Hollywood royalty Sylvester Stallone popped in for a meal at Nonnas on Ecclesall Road after appearing for a talk at Sheffield City Hall in January 2015 – and loved it so much he stayed until the early hours! Photo: submit
4. Public Enemy
A passer-by gave hip hop act Public Enemy a lift to their gig at the Sheffield Arena in 2015 from Fulwood Road after the taxi that was supposed to take them there didn't turn up. Photo: Ethan Miller