The work will involve laying anti-skid surfacing and road markings and will affect several roads.
The outbound lane of Cantley Lane, where it meets Bawtry Road, will be closed for four and a half hours from 7.30pm to midnight on Saturday September 15.
The inbound lane of Cantley Lane at its junction with Bawtry Road will be closed from midnight on Saturday until 7am on Sunday.
And the outbound lane of Bawtry Road at its junction with Cantley Lane will be closed for 12 hours from 7am to 7pm on Sunday.
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Doncaster Council says the closures are essential for the safety of the workforce and the public and will enable the work to be completed more efficiently.
Temporary traffic diversions will be signposted.
Residents living on the route are being told access to their homes will be maintained at all times.