The branch, the restaurant's 21st outlet in the UK is located in the Oasis dining area and serves up favourites such as tacos and burritos.
Barburrito CEO Morgan Davies said: “This is a huge milestone for Barburrito – our 21st store.
"I am thrilled to be opening in Sheffield, Meadowhall.
"It is a fantastic destination with a thriving shopping environment. We are passionate about serving high-quality, fresh and tasty food at an affordable price and we look forward to welcoming Sheffield residents to Barburrito.”
The fast-food chain was founded in 2005 and now has stores in major conurbations across the UK, including London, Liverpool, Leeds, Manchester, Cardiff and Edinburgh.
Its 22nd restaurant is set to open in the Into shopping centre in Derby in the autumn.