The M180 is closed eastbound between junction one near Thorne, Doncaster and junction five of the M18.
A Highways England spokesman said: "Drivers on the M180 near Thorne are being advised to allow extra time for their journeys this morning following a lorry fire.
"The eastbound carriageway is currently closed between the between the M18 and junction 1 at Thorne.
"Traffic officers from Highways England are working with the emergency services at the scene, and a diversion is in place along the A630 and A18.
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"Drivers are being advised to allow extra time to complete their journeys or to consider using alternative routes."