Nsiala, who had earlier equalised Lucas Joao's opener, slid in for the ball and the onrushing Fernando Forestieri appeared to try and avoid the Town player, only for referee Jeremy Simpson to immediately hand out a straight red card.
Just a few minutes later, Joao scored his second of the game and Wednesday went on to win the match 2-1.
'I don't feel I need to say anything. Everyone's seen it,' said Hurst.
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'I've been told that their guys have said it's a totally wrong decision. I'm trying to be careful with my words because it seems as though we can't criticise people when they get things wrong, which isn't right. I criticise my players, I'm sure people criticise me. If you feel people are getting things wrong '¦Â it's his job, he's got to do better than that.'
Asked how the decision influenced the game he added: 'A hell of a lot. It has to. It gives them that lift, it's not long after when they score. We are a man light for those situations. He's arguably our best header (of the ball), one of them, off the pitch. Would he head it? No one knows for certain. I dare say he certainly helps out. It was in an area where he would be.
'Even with 10 men I thought Wednesday were relieved for the final whistle - they weren't comfortable. We didn't have many scares in truth.'
When asked if he was going to appeal against the red card, Hurst added: "Everyone's telling us we should.
"I've seen decisions before in the past where someone's appealed and they still don't overturn them when we have a room full, and one person thinks opposite.
"I don't know what our lad's supposed to do after he's won the ball. Is his leg supposed to drop off?! I just don't know."