Thousands of women will be dressing in pink and donning their trainers to take part in the Race for Life on Sunday.
The 5km event, held in aid of Cancer Research UK, is happening at Meadowhall at 9.30am. Last year about 5,000 people took on the course around the outside of the shopping centre, raising £250,000.
Among the 2015 entrants will be Jayne Murray, from Tinsley, who was diagnosed with lung cancer two years ago after suffering a persistent cough.
She underwent surgery to remove the lung following her diagnosis and was then treated with chemotherapy for four months following the procedure.
“Cancer affects so many of us and it’s thanks to research and treatment that I’m still here today,” said Jayne, aged 53, who will run alongside her daughter Rebecca, 18.
Road closures will be in place around Meadowhall from 7.30am on the day, with access to the centre’s pink car park only.
Extra tram services are being laid on at 7.30am from Middlewood park and ride, and at 7.18 and 7.59 from Halfway.