The collision happened on the southbound stretch of the M18 between junctions 2 and 3, between Edlington and Loversall, Doncaster.
All the vehicles have been moved onto the hard shoulder and recovery trucks are on their way to the crash scene.
Chesterfield Road Sheffield: Man who spent 12 hours on roof is sentenced in court for affray and harassment
Sheffield Council employees sacked as fraud increases including theft and excessive internet use during work
EuroMillions: Mystery winner from South Yorkshire has won £79,242.50 on The National Lottery
Remembering 'beautiful' and 'amazing' Blake and Tristan Barrass three years on from tragic Sheffield brothers' funeral
Sheffield Council tenant forced to pay £5,000 and struck from housing register for fraud