The Grand Slam-winning 10-12 axis of Ford and Owen Farrell are reunited for the bid to complete an historic series triumph against one of the southern hemisphere giants.
Ford starts at fly-half and Farrell moves to inside centre in a positional switch, taking the place of Luther Burrell who is omitted from the 23 altogether.
Marland Yarde is also jettisoned from the team that prevailed 39-28 in Brisbane last Saturday, making way for Nowell on the left wing.
“George and Owen playing together gives us two great kicking options and Jack is a high work-rate player,” head coach Eddie Jones said.
* England team: M Brown (Harlequins); A Watson (Bath), J Joseph (Bath), O Farrell (Saracens), J Nowell (Exeter); G Ford (Bath), B Youngs (Leicester); M Vunipola (Saracens), D Hartley (Northampton, capt), D Cole (Leicester), M Itoje (Saracens), G Kruis (Saracens), C Robshaw (Harlequins), J Haskell (Wasps), B Vunipola (Saracens). Replacements: J George (Saracens), M Mullan (Wasps), P Hill (Northampton), J Launchbury (Wasps), C Lawes (Northampton), J Clifford (Harlequins), D Care (Harlequins), E Daly (Wasps).