The 27-year-old Texan-based fighter, who stopped Brook at Bramall Lane after the home fighter suffered a broken eye socket injury, will face Lamont Petersen.
The Brook win was Spence’s only outing in 2017 - and one he described as a “legacy-defining fight.”
Brook, meanwhile, has announced he would be making a return to the ring in February.
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*Brook Stablemate Atif Shafiq, who boxed on the undercard at the May show, returns to Bramall Lane on a five-fight bill on Friday, November 17.
Kyle Yousaf and Sam O’maison are also scheduled to compete, as are Razaq Najib and Loua Nassa.