South Yorkshire Police said three cars were involved in a collision on Bawtry Road, Wickersley, just before 9.50am.
Police, firefighters and paramedics were deployed to the scene and two casualties had to be cut free by firefighters.
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Four people are believed to have sustained minor injuries.
The collision occured close to Bawtry Road Service Station.
Buses were diverted while enquiries were carried out at the scene but the road has since re-opened.