The University of Sheffield was named the 82nd best university in QS' World University Rankings, rising two placed from last year.
The university was also ranked the 13th best university in the UK.
QS ranks universities on teaching, research and international reputation.
Only five universities in the UK improved from last year's rankings.
President and Vice-Chancellor of the University of Sheffield, Professor Sir Keith Burnett, said the results were encouraging.
He said: "Our University is rightly known internationally for the standard of our scholarship and teaching."