The bridge collapsed near the Italian city of Genoa, leading to vehicles falling some 100m, shortly before noon today during heavy rain.
The head of the local ambulance service was quoted by one source as saying there were "dozens of dead" while police sources confirmed at least 10 people had died.
It is reported one of the towers holding up the suspension bridge collapsed in stormy weather.
The bridge, built in the 1960s, is known as the Morandi bridge.
The missing section was dozens of metres in length, and ran across the span of the Polcevera stream.