Sheffield residents who plan to quit smoking have the chance to be at the forefront of cardiovascular research at one of the city's universities.
Sheffield Hallam University is looking for recruits to take part in a three-year study into the benefits and risks of using e-cigarettes to stop smoking.
More than 250 people are required to take part in the study. Their progress followed over a six-month period.
They will be split into three groups: One group will use nicotine rich e-cigarettes and another will use nicotine-free e-cigarettes.
The third will have access to nicotine replacement therapy. They will be referred to Sheffield's stop smoking services.
The participants will be given free e-cigarette kits and liquids for the study.
The participants' cholesterol and nicotine dependence will be studied throughout the research.
Their arteries will also be examined, along with carbon monoxide in their breath.
The study aims to 'bridge a knowledge gap' regarding the long-term effects of e-cigarettes on the veins and arteries of their users.
Senior research fellow in clinical physiology, Dr Markos Klonizakis, expected plenty of interest from perspective participants.
He said they must be willing to give up the habit.
"Additionally, although they may have an inclination as of in which group they would like to be, they should be ready to follow the group that they are going to be in," he said.
"Which is either one of the two e-cigarette groups or that following the procedures of the stop smoking services."
He also said potential participants shouldn't be using e-cigarettes or stop smoking services at the time they sign up.
The study, which will cost almost £145,000, is funded by Heart Research UK, under the organisation's translational grant scheme.
Dr Klonizakis said the team was pleased to secure the money to conduct the research
"We are proud to have received such prestigious funding, overcoming strong competition by long-standing, high-quality research groups, which applied to the same funding pot with other worthy ideas," he said.
He said residents needed to get behind the project.
"This study can only be successful if people from Sheffield support it," Dr Klonizakis said.
"It is a great opportunity for Sheffield to be in the forefront of cardiovascular research, but we won't make it without them."
To register your interest in the study, contact Gareth Jones on 0114 225 4312 or e-mail HeartResearch@shu.ac.uk.