Zayn Imran was last seen in the Wombwell area of Barnsley on Thursday (May 6).
He is believed to be wearing a black jumper and dark coloured jogging bottoms.
The police said the teenager has links to Rotherham and Sheffield.
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Those with information are urged to contact 101 quoting incident number 1014 of May 6.
They can also make a report using the police’s online portal.