The murder suspects are due to appear at Sheffield Crown Court over the death of Jarvin Blake, aged 22, who was stabbed to death in Burngreave in March 2018.
Jarvin, who had three children under five, was knifed in broad daylight at the junction of Catherine Street and Brackley Street.
A 23-year-old man also injured during the attack has since made a full recovery.
Josiah Foster, 26, of the Manor, Sheffield; Lewis Barker, 26, of Parson Cross, Sheffield; Devon Walker, 24, of Burngreave, Sheffield and Caine Gray, 27, of Treeton, Rotherham, are all charged with charged with murder.
Walker is also charged with assault occasioning actual bodily harm over the attack on Jarvin's friend.