An area of Brimmesfield Close, Arbourthorne, is sealed off and under police guard this morning.
No details have yet been released by South Yorkshire Police, but there are officers around the crime scene near a block of flatts, which is taped off.
Police activity is also under way on the Arbourthorne estate in the wake of a recent shooting.
A 12-year-old boy was injured in a drive-by shooting on Northern Avenue on Sunday, January 12 and in the wake of the attack the estate has been flooded by officers.
Four arrests have been made over the shooting and a number of other arrests have also been made in a crime blitz in Arbourthorne, Manor and Heeley as officers attempt to disrupt organised crime groups.
Police chiefs have vowed to continue stop and search checks on the estate for the foreseeable future and armed officers are among those involved in extra police patrols mounted since the shooting.
Stephen Dunford, 25, of Fellbrigg Road, Arbourthorne, remains on remand charged with attempted murder and possession of a firearm with intent to endanger life over the shooting.
Two 30-year-old men arrested on suspicion of the same offences were bailed and a 42-year-old woman arrested yesterday on suspicion of conspiracy to murder and possession of a firearm with intent to endanger life remains in police custody today.
Anyone with information should call 101.