The summer transfer window saw a flurry of signings for both sides, with United's Oliver Norwood and City's Andreas Weimann already impressing early in the season for their new clubs.
What time isÂ kick off?
Kick off at Ashton Gate is at 3pm on Saturday 15 September.
Is the matchÂ on TV? Can I watch itÂ on a live stream?
The match is not being shown by Sky Sports or via live stream on iFollow, but match commentary should be available on the iFollow AudioÂ service.
How can I follow United v BristolÂ live?
You'll be able to follow all the latest updates and team news on The Star website.
Who will be in the teams for the match?
United's new signings Marvin Johnson and Martin Cranie should be eligible, while Paul Coutts could finally make his first team return after being on the sidelines since breaking his leg last season.
Coutts played in the Blades friendly match against Sheffield FC and has been in action for the under-23s during the international break.
Leon Clarke may also return after missing the last match against Aston Villa through injury '“Â he has returned to training this week.
Andreas Wiemann has been on excellent form for the Robins since joining from Derby County and has been nominated for the August Championship player of the month award for his five goals in six league matches.
Who is the referee?
Referee appointments have not yet been announced.
What are the betting odds?
Sky Bet have Sheffield United to win at 13/8, a draw at 23/10 and a Bristol win at 13/8.
What is the form of United and City?
The Blades are riding high and come into the fixture on the back of four leagueÂ victories against QPR, Norwich, Bolton and Villa, and are currently 3rdÂ in the table.
Bristol have also had a strong start to the season and are just one point behind Chris Wilder's side in 6th place after three straight wins.
However the Robins have only won one match at home so far this season, which could work in United's favour.