Moe, a female terrier cross, went missing from the Clay Lane area of Doncaster last weekend - and an appeal has been launched on Facebook to get her back.
The animal is white and light brown in colour, is microchipped and was wearing a colour with no tag at the time of her disappearance at around 11am on June 17.
She was last sighted on Clay Lane near Sandall Park - although there was a sighting of her in Queen's Road near the town centre about an hour later.
A campaign organiser said: "She is tiny and will be terrified. She is a small dog and nervous.
"Her owners are elderly and are on holiday. As you can imagine, they are distraught and the grand-daughter and family are out searching constantly."
Anyone with any sightings of Moe should contact 07926 429112 or contact the police on 101.