Emergency services were called out to Bowshaw, Dronfield close to the Sheffield/Derbyshire border at around 11.30pm on Friday night.
The incident involved one-vehicle and a man and woman were suffered injuries.
A spokesman for Derbyshire Fire and Rescue said: “A crew from Dronfield attended a road traffic collision involving one vehicle on Bowshaw, Dronfield.
“They gave trauma care and assisted the Yorkshire Ambulance Service with one male casualty before his conveyance to hospital.
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“One female casualty received medical care from ambulance personnel.
“Derbyshire Police and the helimed also attended."