The charity homes the animals, some of which were abandoned or whose owner passed away, at a centre on Stadium Way.
Regardless of how they end up there, the animals are looked after until a new home can be found.
The RSPCA also offers advice to people who already own pets but may be struggling to cope with the cost of food or healthcare.
The round up includes a duo of kittens who love chasing each other and another pair of cats who love to bump heads with their owners.
Here are around half of the centre’s animals that have not yet been matched up with their forever home.
You can find even more animals in need of a family on the Sheffield RSPCA branch’s website.
If you are interested in applying, send a completed application form to [email protected].

9. Pat
Pat the cat was sadly left in the foyer at RSPCA's Sheffield branch, so his history is unknown. He is confident with a carefree attitude, and loves exploring outside his pen. He is polite and friendly but very independent, sometimes ignoring what staff need from him! He is a bold boy who likes a fuss and cuddle, but also likes to have an adventure. He could live with older children, or possibly another cat depending on their personality. | RSPCA

10. Hazel and Casper
This lovely pair are both very happy and playful kittens. They would benefit from a home together as they are quite bonded. Both enjoy a fuss, and love chasing each other (or a crinkly ball). | RSPCA